Mechanism of oral tolerance induction to therapeutic proteins
نویسندگان
چکیده
منابع مشابه
Immunological Tolerance: Therapeutic Induction
Immunological tolerance can be defined as an unresponsiveness of T and/or B cells to self antigens. Low responsiveness of T cells and/or B cells to self antigens could be termed partial tolerance. Protection from the development of autoimmune diseases and acceptance of transplanted organs or tissue are due to effective tolerance to self antigens and alloantigens, respectively. The breakdown of ...
متن کاملThe concept of oral tolerance induction to foods.
The conventional wisdom is that early exposure to allergenic food proteins during pregnancy, lactation, or infancy leads to food allergies, and that prevention strategies should therefore aim to eliminate allergenic food proteins during pregnancy, breastfeeding, and early childhood. Prolonged exclusive breastfeeding and delayed weaning onto solid foods is therefore seen as an effective public h...
متن کاملExploiting apoptosis for therapeutic tolerance induction.
Immune tolerance remains the most promising yet elusive strategy for treating immune-mediated diseases. An experimental strategy showing promise in phase 1 clinical studies is the delivery of Ag cross-linked to apoptotic leukocytes using ethylene carbodiimide. This approach originated from demonstration of the profound tolerance-inducing ability of i.v. administered Ag-coupled splenocytes (Ag-S...
متن کاملOral Tolerance: Therapeutic Implications for Autoimmune Diseases
Oral tolerance is classically defined as the suppression of immune responses to antigens (Ag) that have been administered previously by the oral route. Multiple mechanisms of tolerance are induced by oral Ag. Low doses favor active suppression, whereas higher doses favor clonal anergy/deletion. Oral Ag induces Th2 (IL-4/IL-10) and Th3 (TGF-beta) regulatory T cells (Tregs) plus CD4+CD25+ regulat...
متن کاملSpecific oral tolerance induction in food allergy.
Specific oral tolerance in food allergy can be induced by oral administration of the offending food, starting with very low dosages, gradually increasing the daily dosage up to an amount equivalent to a usually relevant dose for daily intake, followed up by a daily maintenance dose. Unfortunately, the body of scientific evidence concerning specific oral tolerance induction (SOTI) is still rathe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2013
ISSN: 0169-409X
DOI: 10.1016/j.addr.2012.10.013